Diseases Treated with Umbilical Cord Blood

Diseases Treated with Umbilical Cord Blood

The umbilical cord blood is rich in stem cells which are termed as hematopoietic cells. These cells have the capability to produce different kinds of cells in the blood i.e. red blood cells, white blood cells and platelets.

It is found that stem cell transplantation cannot be used to treat all kinds of diseases but can treat more than 70 different types of diseases. Researchers have found that stem cells stored from umbilical cord can be used to treat various types of cancers, disorders and abnormalities.

With the success of stem cell transplantation in 1988 stem cells have been used to treat various diseases through stem cell transplants. The major advantage of stem cell transplants is that there is no requirement for a perfect donor match like in a bone marrow transplant and cord blood is available in cord blood banks, which can be made available.

Diseases that are treated by stem cells are:

1) Acute Leukemia

• Acute Lymphoblast Leukemia (ALL)
• Acute Myelogenous Leukemia (AML)
• Acute Biphenotypic Leukemia
• Acute Undifferentiated Leukemia

2) Chronic Leukemia

• Chronic Myelogenous Leukemia (CML)
• Chronic Lymphocytic Leukemia (CLL)
• Juvenile Chronic Myelogenous Leukemia (JCML)
• Juvenile Myelomonocytic Leukemia (JMML)
• Myelodysplastic Syndromes
• Amyloidosis
• Chronic Myelomonocytic Leukemia (CMML)
• Refractory Anemia (RA)
• Refractory Anemia with Excess Blasts (RAEB)
• Refractory Anemia with Excess Blasts in Transformation
• (RAEB-T)
• Refractory Anemia with Ringed Sideroblasts (RARS)


1) Stem Cell Disorders

• Aplastic Anemia (Severe)
• Fanconi Anemia
• Paroxysmal Nocturnal Hemoglobinuria (PNH)
• Congenital Cytopenia
• Dyskeratosis Congenita

2) Myeloproliferative Disorders

• Acute Myelofibrosis
• Agnogenic Myeloid Metaplasia (myelofibrosis)
• Polycythemia Vera
• Essential Thrombocythemia

3) Lymphoproliferative Disorders

• Non-Hodgkin’s Lymphoma
• Hodgkin’s disease
• Prolymphocytic Leukemia

4) Phagocyte Disorders

• Chediak-Higashi Syndrome
• Chronic Granulomatous Disease
• Neutrophil Actin Deficiency
• Reticular Dysgenesis

5) Inherited Metabolic Disorders

• Mucopolysaccharidoses (MPS)
• Hurler’s Syndrome (MPS-IH)
• Scheie Syndrome (MPS-IS)
• Hunter’s Syndrome (MPS-II)
• Sanfilippo Syndrome (MPS-III)
• Morquio Syndrome (MPS-IV)
• Maroteaux-Lamy Syndrome (MPS-VI)
• Sly Syndrome, Beta-Glucuronidase Deficiency (MPS-VII)
• Adrenoleukodystrophy
• Mucolipidosis II (I-cell Disease)
• Krabbe Disease
• Gaucher’s Disease
• Niemann-Pick Disease
• Wolman Disease
• Metachromatic Leukodystrophy

6) Histiocytic Disorders

• Familial Erythrophagocytic Lymphohistiocytosis
• Histiocytosis-X
• Hemophagocytosis
• Langerhans’ Cell Histiocytosis

7) Inherited Immune System Disorders

• Ataxia-Telangiectasia
• Kostmann Syndrome
• Leukocyte Adhesion Deficiency
• DiGeorge Syndrome
• Bare Lymphocyte Syndrome
• Omenn’s Syndrome
• Severe Combined Immunodeficiency (SCID)
• SCID with Adenosine Deaminase Deficiency
• Absence of T & B Cells SCID
• Absence of T Cells, Normal B Cell SCID
• Common Variable Immunodeficiency
• Wiskott-Aldrich Syndrome
• X-Linked Lymphoproliferative Disorder

8) Other Inherited Disorders

• Lesch-Nyhan Syndrome
• Cartilage-Hair Hypoplasia
• Glanzmann Thrombasthenia
• Osteopetrosis
• Adrenoleukodystrophy
• Ceroid Lipofuscinosis
• Congenital Erythropoietic Porphyria
• Sandhoff Disease

9) Plasma Cell Disorders

• Multiple Myeloma
• Plasma Cell Leukemia
• Waldenstrom’s Macroglobulinemia
• Amyloidosis


1) Inherited Platelet Abnormalities

Amegakaryocytosis / Congenital Thrombocytopenia

2) Inherited Erythrocyte Abnormalities

• Beta Thalassemia Major
• Sickle Cell Disease
• Blackfan-Diamond Anemia
• Pure Red Cell Aplasia

Other Malignancies

• Ewing Sarcoma
• Neuroblastoma
• Renal Cell Carcinoma
• Retinoblastoma
• Brain tumor
• Ovarian Cancer
• Small Cell Lung Cancer
• Testicular Cancer

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2 Comments For This Post

  1. Cyber Monday Says:

    very interesting. thanks for the insight.


  2. Steve Gerrior Says:

    I am a student nurse, and currently in a OBGYN clinical rotation. Cord blood donation is an excellent way to give back to science and medicine and humanity. I encourage any term or pre-term mom to make the decision to donate cord blood during their child’s birth. From what I have seen it is quick, painless and does not hurt the baby. An easy decision that can be made any time up to the birth of the placenta.

    Donate cord blood your saving lives!!!!

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